The spectrum of clinical syndromes termed chronic heart failure (CHF) represents the advanced, terminal stage of progression in a variety of heart conditions. Its relentless rise in morbidity and mortality signifies a serious concern for public health and individual safety. The etiology of congestive heart failure is multifaceted, encompassing complex and diverse diseases, such as coronary heart disease, hypertension, diabetes, cardiomyopathy, and so forth. For comprehensive understanding of CHF pathogenesis and to develop effective preventive and therapeutic agents against diverse disease-induced CHF, the development of animal models for CHF, stratified by the etiology, is indispensable. Consequently, categorizing the root causes of congestive heart failure (CHF), this paper comprehensively reviews animal models of CHF employed over the past decade, along with their application in traditional Chinese medicine (TCM) research. This aims to offer insights and strategies for investigating the development and treatment of CHF, thereby fostering TCM modernization.
The 'eight trends' in the 2021 Chinese medicinal materials (CMM) market were the subject of this paper, which also analyzed the production issues affecting CMM and presented developmental suggestions. The following eight trends are summarized, specifically:(1) In the CMM sector, growth remained constant, and certain provinces started issuing local directories of Dao-di herbs. BLU222 The process of protecting new plant varieties progressed rapidly, and this spurred the creation of many top-quality varieties. With ecological cultivation theory receiving further refinement, the demonstrable impact of the cultivation technology was readily apparent. BLU222 Model instances, typical and predictable, emerged from the completely mechanized CMM systems. The adoption of the traceability platform by cultivation bases grew, while provincial online trading platforms were introduced. In tandem with the accelerated construction of CMM industrial clusters, a dramatic rise in the number of provincial-level regional brands occurred. A proliferation of agricultural businesses across the nation utilized a range of approaches to spur the enhanced development of CMM. Local TCM ordinances were promulgated, accompanied by a regulatory document governing the management of food and medicine homology substance catalogs. On the strength of this, four proposals for CMM manufacturing were put forward. A faster compilation of the national Dao-di herb catalog and the certification of Dao-di herb production bases are recommended. For the advancement of ecological planting of forest and grassland medicinal resources, further exploration and implementation of superior technical research and promotion approaches aligned with ecological principles are essential. Prioritizing basic disaster prevention efforts while simultaneously developing sophisticated technical strategies for disaster reduction is essential. For comprehensive national statistical reporting, the planted area data of commonly used CMMs should be integrated into the regular system.
It is widely accepted that the microbiome and traditional Chinese medicine (TCM) have a strong and intricate relationship. BLU222 The field of microbiomics has been revolutionized by recent advancements in high-throughput sequencing and multi-omics technologies, yielding a plethora of new technologies, results, and theories. Previous studies informed this current research, which proposes TCM microbiomics (TCMM), an interdisciplinary field dedicated to understanding the functions and applications of the microbiome in herb resources, herb processing, herb storage, and clinical effects, utilizing advanced biological, ecological, and informatic methodologies. The subject matter encompasses the structures, functions, interactions, molecular mechanisms, and practical applications of the microbiome, directly relating to the quality, safety, and effectiveness of traditional Chinese medicine. Initially, the conceptualization of the TCMM framework was outlined, highlighting the TCMM's comprehensive grasp of the intricacies and entirety of the microbiome. This paper examines the research and applications of TCMM in achieving sustainable herb resource management, enhancing herb fermentation standardization and diversification, improving herb storage safety, and elucidating the scientific principles behind TCM theories and clinical applications. Conclusively, a detailed explanation of TCM microbiomics' research strategies and methods was presented through basic, application-oriented, and systemic research models. To modernize TCM, TCMM is expected to synergize its principles with the latest scientific and technological innovations, leading to a more comprehensive understanding and improved modernization of TCM.
As a traditional Chinese medicine dosage form, the lozenge plays a significant role. In all Chinese dynastic medical texts, originating from the Eastern Han Dynasty, records of its use have been meticulously documented and continuously developed over time. The distinctiveness of its pharmaceutical methods and the encompassing range of their applications are the driving forces behind its emergence, continuation, and evolution. Thus far, the Chinese Pharmacopoeia has maintained lozenge's status as a self-contained dosage form. Chinese medicine pharmaceutics has recontextualized the lozenge, demanding a tracing of its historical origins and an assessment of its modern value. A comprehensive study of lozenge's genesis and progress was undertaken, analyzing both modern and historical forms while comparing them to alternative dosage forms. The study discussed future prospects of lozenges, particularly within the rapidly growing field of modern Chinese medicine preparations. The aim was to inform the broader application of lozenge formulations in contemporary medicine.
Human wisdom is evident in the long history and substantial experience of Traditional Chinese Medicine (TCM) in external therapy applications. The early human experience revealed that the processes of fumigating, coating, and binding tree branches and herbal stems were effective in easing the discomfort of scabies and removing parasitic infestations from the workforce, thereby establishing the foundation of external therapy. The body's surface is a common portal for pathogen entry, justifying the use of external therapies to treat the condition. A key characteristic of TCM surgical practice is the utilization of external therapies. By externally stimulating acupoints, a Traditional Chinese Medicine technique, the meridians and collaterals facilitate energy flow to the zang-fu organs, thereby harmonizing the opposing forces of yin and yang. The therapy's roots trace back to early societies, flourishing through the Spring and Autumn and Warring States periods, further refined during the Song and Ming dynasties, and reaching its apex during the Qing dynasty. The expertise of historians has contributed to the development of a well-rounded theory. Recent studies show Chinese medicine can bypass liver metabolism and reduce gastrointestinal discomfort, leading to improved absorption rates. By stimulating acupoints and employing the theoretical framework of Chinese medicine, particularly the meridian and collateral theory, optimal results from Traditional Chinese Medicine and the combined effect of both are achieved. Through this process, it controls the flow of qi and blood, and maintains the equilibrium of yin and yang, hence contributing to its extensive application in managing illnesses. This study, leveraging a literature review, comprehensively investigated external acupoint applications, encompassing their influence on skin immunity, neuro-inflammatory pathways, their correlations with human circulatory networks, and the evolution of effective dosage forms. This research is projected to provide a platform for subsequent explorations, stemming from this premise.
Pathological events, disease development, and treatment responses in mammals are modulated by the circadian rhythm, an internal regulatory mechanism formed in response to the environmental circadian periodicity. The element plays a significant role in determining the susceptibility to ischemic stroke, the resulting harm, the recuperative process, and the efficacy of therapeutic interventions. Research indicates circadian rhythms exert control over not only essential physiological processes in ischemic strokes, including blood pressure and coagulation-fibrinolysis, but also the immuno-inflammatory response initiated by glial cells and peripheral immune cells after ischemic injury, and the regulation of the neurovascular unit (NVU). The circadian interplay between molecular, cellular, and physiological processes in biology is examined within the context of ischemic stroke, highlighting the impact of these rhythms on stroke pathogenesis, the neurovascular unit, and immune-inflammatory reactions. Examining the efficacy of traditional Chinese medicine in regulating circadian rhythms, this analysis also summarizes current research trends regarding TCM interventions. This effort offers valuable insights for future research in TCM and the molecular basis of circadian rhythms.
Actively dividing transit amplifying cells (TACs) reside within hair follicles (HFs), making them acutely vulnerable to radiotherapy (RT). A clinical deficit exists in the treatment of radiotherapy-induced alopecia (RIA).
Our present study sought to uncover the consequences and underlying processes of applying local prostaglandin E2 (PGE2) for the purpose of preventing RIA.
Using a live mouse model, we examined the response of developing high-frequency cells to radiation, evaluating the influence of local PGE2 pretreatment prior to exposure. The effect of PGE2 on the cell cycle was evaluated in cultured HF cells from fluorescent ubiquitination-based cell cycle indicator mice. In addition, we evaluated the protective actions of PGE2 and a cyclin-dependent kinases 4/6 (CDK4/6) inhibitor in comparison with RIA.
The local cutaneous PGE2 injection contributed to the improvement of the heart's high-frequency self-repair processes, thus reducing the RIA.